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Calreticulin rabbit pAb

簡(jiǎn)要描述：SourceRabbitApplicationsWBReactivityHuman

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  • 廠(chǎng)商性質(zhì)：生產(chǎn)廠(chǎng)家
  • 更新時(shí)間：2025-07-27
  • 訪(fǎng)  問(wèn)  量：181

詳細(xì)介紹

  • Source

    Rabbit

  • Applications

    WB

  • Reactivity

    Human, Mouse, Rat

  • Dilution

    WB 1:500-2000

  • Storage

    -20°C/1 year

  • Specificity

    This antibody detects endogenous levels of human Calreticulin

  • Source/Purification

    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

  • Immunogen

    Recombinant Protein derived from human Calreticulin

  • Uniprot No

    P27797

  • Alternative names

    Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    calreticulin(CALR) Homo sapiens Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its

  • Other

    CALR CRTC, Calreticulin

  • Concentration

    1 mg/ml

Product Reactivity Applications Conjugation Catalog Images

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