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Calregulin rabbit pAb

簡要描述：SourceRabbitApplicationsWB,IHC,IF,ELISAReactivityHuman,Mouse,Rat,MonkeyDilutionWB:1:500-1:2000

  • 產品型號：
  • 廠商性質：生產廠家
  • 更新時間：2025-07-27
  • 訪  問  量：211

詳細介紹

  • Source

    Rabbit

  • Applications

    WB,IHC,IF,ELISA

  • Reactivity

    Human,Mouse,Rat,Monkey

  • Dilution

    WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. IF: 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    Calregulin Polyclonal Antibody detects endogenous levels of Calregulin protein.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    The antiserum was produced against synthesized peptide derived from human CALR. AA range:21-70

  • Uniprot No

    P27797

  • Alternative names

    CALR; CRTC; Calreticulin; CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP; grp60

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    calreticulin(CALR) Homo sapiens Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its

  • Other

    CALR, Calreticulin

  • Mol.Wt (Da)

    48142

  • Concentration

    1 mg/ml

Product Reactivity Applications Conjugation Catalog Images

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