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Caspase-8 (phospho Ser347) rabbit pAb

簡要描述：SourceRabbitApplicationsWB,IHC,ELISAReactivityHuman,RatDilutionWB:1:500-1:2000

  • 產品型號：
  • 廠商性質：生產廠家
  • 更新時間：2025-07-27
  • 訪  問  量：178

詳細介紹

  • Source

    Rabbit

  • Applications

    WB,IHC,ELISA

  • Reactivity

    Human,Rat

  • Dilution

    WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.

  • Storage

    -20°C/1 year

  • Specificity

    Phospho-Caspase-8 (S347) Polyclonal Antibody detects endogenous levels of Caspase-8 protein only when phosphorylated at S347.

  • Source/Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

  • Immunogen

    The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Ser347. AA range:313-362

  • Uniprot No

    Q14790

  • Alternative names

    CASP8; MCH5; Caspase-8; CASP-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; MACH

  • Form

    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

  • Clonality

    Polyclonal

  • Isotype

    IgG

  • Background

    caspase 8(CASP8) Homo sapiens This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alt

  • Other

    CASP8, Caspase-8

  • Mol.Wt (Da)

    55391

  • Concentration

    1 mg/ml

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